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EurasiaHealth AIDS Knowledge Network. Up-to date Russian-language information on the treatment and prevention of HIV/AIDS

Resources for Health Professionals and Patients

Search Details Submited by: "Victor Stanilevskiy "
Number of Items Found: 118
Search Results
Coinfection with Hepatitis Viruses and HIV
Attached file: 
 pdf file (Russian, 404.4 kb) Coinfection with Hepatitis Viruses and HIV 
Link to document(s)
 http://www.hivinsite.com/In...
Author(s): 
 Khalili M.
Description: 
 There are about 150 million chronic hepatitis C virus (HCV) carriers throughout the world, with an estimated global prevalence of 3% (range 0.1-5%). Chronic HCV infection can lead to cirrhosis and hepatocellular carcinoma, resulting in 8,000-10,000 deaths annually in the United States alone. Additionally, HCV-induced end-stage liver disease accounts for about 30% of liver transplants in industrialized countries, presenting a significant burden on health care costs. HIV/HCV coinfection is common, with an especially high prevalence among IDUs. HIV coinfection may enhance the sexual and vertical transmission of HCV.
Language: 
 English, Russian
Primary area(s) of focus: 
 HIV/AIDS
Pages: 
 27
Serious Bacterial Infections in Children with HIV
Attached file: 
 pdf file (Russian, 392.9 kb) Serious Bacterial Infections in Children with HIV 
Link to document(s)
 http://www.hivinsite.com/In...
Author(s): 
 Jankelevich S.
Description: 
 Numerous defects in the immunologic system are responsible for the increased vulnerability of HIV-infected children to serious bacterial illness. These include defects in the cell-mediated (T-cell) and the humoral (B-cell) arms of the immune system; phagocytic abnormalities including decreases in neutrophil number, multiple defects in neutrophil function, and impairment in macrophage and monocyte function; functional asplenia; and defects in 3 components of complement. These defects become more severe as the child's HIV disease progresses. Extrinsic factors in industrialized countries that increase susceptibility to infection in HIV-infected children include frequent use of broad-spectrum antibiotics, frequent hospitalizations, and the use of indwelling intravascular catheters that disrupt the integrity of skin. Major factors in developing countries include malnutrition, micronutrient deficiencies, and lack of adequate medical care. The results of these defects are increased susceptibility to infection with encapsulated bacteria beyond age 2 years, increased nasopharyngeal colonization rates for Streptococcus pneumoniae and Haemophilus influenzae, recurrent infections with the same bacterial species, increased susceptibility to infections with bacteria unusual in immunocompetent hosts, and increased morbidity and mortality.
Language: 
 English, Russian
Primary area(s) of focus: 
 HIV/AIDS
Pages: 
 19
Review: CD4-guided scheduled treatment interruptions compared with continuous therapy for patients infected with HIV-1: results of the Staccato randomised trial
Attached file: 
 pdf file (Russian, 287.9 kb) Review: CD4-guided scheduled treatment interruptions compared with continuous therapy for patients infected with HIV-1: results of the Staccato randomised trial 
Link to document(s)
 http://www.ncbi.nlm.nih.gov...
Author(s): 
 Ananworanich J. et. al
Description: 
 В связи с выраженной токсичностью высокоактивной антиретровирусной терапии (ВААРТ) и ее высокой стоимостью в медицинском мире продолжается дискуссия о возможных плановых перерывах ВААРТ.
Исследование Staccato было начато как сравнительное испытание двух методик прерывистой ВААРТ: методики ВААРТ «через неделю», которая предполагала остановку ВААРТ на 1 неделю после каждой недели лечения и методики плановых перерывов ВААРТ, назначавшихся в зависимости от уровня CD4 клеток. После промежуточного анализа, показавшего высокий процент неудачи терапии в группе ВААРТ «через неделю», эту ветвь исследования остановили.
Данная работа ставила целью сравнить эффективность и безопасность непрерывной ВААРТ и ВААРТ с плановыми перерывами (ВПП) для ВИЧ инфицированных больных.
Language: 
 English, Russian
Primary area(s) of focus: 
 HIV/AIDS
Pages: 
 4
Review: HIV treatment response and prognosis in Europe and North America in the first decade of highly active antiretroviral therapy: a collaborative analysis.
Attached file: 
 pdf file (Russian, 275.9 kb) Review: HIV treatment response and prognosis in Europe and North America in the first decade of highly active antiretroviral therapy: a collaborative analysis. 
Link to document(s)
 http://www.ncbi.nlm.nih.gov...
Author(s): 
 May M., et. al
Description: 
 Highly active antiretroviral therapy (HAART) for the treatment of HIV infection was introduced a decade ago. The study aimed to examine trends in the characteristics of patients starting HAART in Europe and North America, and their treatment response and short-term prognosis.
Language: 
 English, Russian
Primary area(s) of focus: 
 HIV/AIDS
Pages: 
 3
Review: Three- vs Four-Drug Antiretroviral Regimens for the Initial Treatment of HIV-1 Infection : a randomized controlled trial.
Attached file: 
 pdf file (Russian, 426.9 kb) Review: Three- vs Four-Drug Antiretroviral Regimens for the Initial Treatment of HIV-1 Infection : a randomized controlled trial. 
Link to document(s)
 http://www.ncbi.nlm.nih.gov...
Author(s): 
 Gulick R. et al.
Description: 
 Three-drug antiretroviral regimens are standard of care for initial treatment of human immunodeficiency virus 1 (HIV-1) infection, but a 4-drug regimen could improve antiretroviral activity and be more effective than a 3-drug regimen.
Language: 
 English, Russian
Primary area(s) of focus: 
 HIV/AIDS
Pages: 
 3
Review: Tuberculin Skin Testing in Patients with HIV Infection: Limited Benefit of Reduced Cutoff Values
Attached file: 
 pdf file (Russian, 273.6 kb) Review: Tuberculin Skin Testing in Patients with HIV Infection: Limited Benefit of Reduced Cutoff Values 
Link to document(s)
 http://www.ncbi.nlm.nih.gov...
Author(s): 
 Cobelens F. et. al
Description: 
 When determining eligibility for isoniazid preventive therapy of human immunodeficiency virus (HIV)-infected patients, the cutoff value of the tuberculin skin test (TST) is often reduced from an induration of 10 mm in diameter to one of 5 mm in diameter to compensate for loss of sensitivity. The effectiveness of this reduction depends on the underlying mechanism: a gradual decrease in skin test responsiveness with decreasing immunocompetence or an all-or-nothing switch to complete anergy. No published studies have assessed this directly in patients with tuberculosis.
Language: 
 English, Russian
Primary area(s) of focus: 
 HIV/AIDS
Pages: 
 3
Review: Durable efficacy of tipranavir-ritonavir in combination with an optimized background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug
Attached file: 
 pdf file (Russian, 284.8 kb) Review: Durable efficacy of tipranavir-ritonavir in combination with an optimized background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug 
Link to document(s)
 http://www.ncbi.nlm.nih.gov...
Author(s): 
 Hicks C. et al.
Description: 
 Treatment options for HIV-1 infected individuals who have received extensive previous antiretroviral therapy are limited. We compared efficacy and safety of the novel non-peptidic protease inhibitor tipranavir co-administered with ritonavir plus an optimised background regimen with that of an investigator-selected ritonavir-boosted comparator protease inhibitor (CPI-ritonavir) in such patients.
Language: 
 English, Russian
Primary area(s) of focus: 
 HIV/AIDS
Pages: 
 3
Review: Persistent Humoral Immune Defect in Highly Active Antiretroviral Therapy-treated Children with HIV-1 Infection: Loss of Specific Antibodies against Attenuated Vaccine Strains and Natural Viral Infection.
Attached file: 
 pdf file (Russian, 280.5 kb) Review: Persistent Humoral Immune Defect in Highly Active Antiretroviral Therapy-treated Children with HIV-1 Infection: Loss of Specific Antibodies against Attenuated Vaccine Strains and Natural Viral Infection. 
Link to document(s)
 http://www.ncbi.nlm.nih.gov...
Author(s): 
 Bekker V. et al.
Description: 
 In the pre-highly active antiretroviral therapy era, a loss of specific antibodies was seen. Our objective with this study was to describe the loss of specific antibodies during treatment with highly active antiretroviral therapy.
Language: 
 English, Russian
Primary area(s) of focus: 
 HIV/AIDS
Pages: 
 3
Guidelines for establishing DOTS-PLUS pilot projects for the management of multidrug-resistant tuberculosis (MDR-TB)
Link to document(s)
 http://www.who.int/docstore...
Link to document(s)
 http://www.who.int/docstore...
Description: 
 Worldwide, tuberculosis (TB), a disease caused by Mycobacterium tuberculosis, is the second greatest contributor among infectious diseases to adult mortality. The World Health Organization (WHO) estimates that two million deaths occur each year from the disease. Of equal note, one third of the world's population is infected with Mycobacterium tuberculosis. The WHO recommended strategy to combat TB, directly observed treatment, short-course (DOTS), can cure over 85% of patients with TB. Of concern, however, is the rise in drug-resistant TB and multidrug-resistant TB (MDR-TB). Several geographical settings with a prevalence of greater than 3% of MDR-TB among newly diagnosed cases have been identified by the WHO/International Union Against Tuberculosis and Lung Disease (IUATLD) Global Project on Drug Resistance Surveillance. In some countries, drug resistance threatens the success of TB control. In order to address drug-resistant TB in general and MDR-TB in particular, WHO (1999) created the Working Group on DOTS-Plus for MDR-TB.
Language: 
 English, Russian
Publication date:
2006
Primary area(s) of focus: 
 DOTS-Plus & MDR-TB, Advocacy, Communication & Social Mobilization (ACSM)
Pages: 
 53
Review: Effect of Perinatal Antiretroviral Drug Exposure on Hematologic Values in HIV-Uninfected Children: An Analysis of the Women and Infants Transmission Study
Attached file: 
 pdf file (Albanian, 279.3 kb) Review: Effect of Perinatal Antiretroviral Drug Exposure on Hematologic Values in HIV-Uninfected Children: An Analysis of the Women and Infants Transmission Study 
Link to document(s)
 http://www.ncbi.nlm.nih.gov...
Author(s): 
 Susan E. Pacheco et al.
Description: 
 This article review was prepared by the Internet project MedMir.com, which is aimed to provide Russian speaking medical professionals with timely, comprehensive and relevant clinical information in the form of the Russian language summaries of clinical study reports published in the top world medical journals.
Language: 
 English, Russian
Publication date:
October 15, 2006
Primary area(s) of focus: 
 HIV/AIDS
Pages: 
 2

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